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Last post 2 years ago by Sunoverbeach. 18 replies replies.
Don’t EVER say Oregon doesn’t contribute to society.
ZRX1200 Offline
#1 Posted:
Joined: 07-08-2007
Posts: 60,477
It’s the premiere food source!!!

CORVALLIS, Ore. (KTVZ) – Hemp compounds identified by Oregon State University research with a chemical screening technique invented at OSU show the ability to prevent the virus that causes COVID-19 from entering human cells.

Findings of the study led by Richard van Breemen, a researcher with Oregon State’s Global Hemp Innovation Center, College of Pharmacy and Linus Pauling Institute, were published today in the Journal of Natural Products.

Hemp, known scientifically as Cannabis sativa, is a source of fiber, food and animal feed, and multiple hemp extracts and compounds are added to cosmetics, body lotions, dietary supplements and food, van Breemen said.


Van Breemen and collaborators, including scientists at Oregon Health & Science University, found that a pair of cannabinoid acids bind to the SARS-CoV-2 spike protein, blocking a critical step in the process the virus uses to infect people.

The compounds are cannabigerolic acid, or CBGA, and cannabidiolic acid, CBDA, and the spike protein is the same drug target used in COVID-19 vaccines and antibody therapy. A drug target is any molecule critical to the process a disease follows, meaning its disruption can thwart infection or disease progression.


“These cannabinoid acids are abundant in hemp and in many hemp extracts,” van Breemen said. “They are not controlled substances like THC, the psychoactive ingredient in marijuana, and have a good safety profile in humans. And our research showed the hemp compounds were equally effective against variants of SARS-CoV-2, including variant B.1.1.7, which was first detected in the United Kingdom, and variant B.1.351, first detected in South Africa.”

Those two variants are also known the alpha and beta variant, respectively.

Characterized by crown-like protrusions on its outer surface, SARS-CoV-2 features RNA strands that encode its four main structural proteins – spike, envelope, membrane and nucleocapsid – as well as 16 nonstructural proteins and several “accessory” proteins, van Breemen said.


“Any part of the infection and replication cycle is a potential target for antiviral intervention, and the connection of the spike protein’s receptor binding domain to the human cell surface receptor ACE2 is a critical step in that cycle,” he said. “That means cell entry inhibitors, like the acids from hemp, could be used to prevent SARS-CoV-2 infection and also to shorten infections by preventing virus particles from infecting human cells. They bind to the spike proteins so those proteins can’t bind to the ACE2 enzyme, which is abundant on the outer membrane of endothelial cells in the lungs and other organs.”

Using compounds that block virus-receptor interaction has been helpful for patients with other viral infections, he notes, including HIV-1 and hepatitis.

Van Breemen, Ruth Muchiro of the College of Pharmacy and Linus Pauling Institute and five scientists from OHSU identified the two cannabinoid acids via a mass spectrometry-based screening technique invented in van Breemen’s laboratory. Van Breemen’s team screened a range of botanicals used as dietary supplements including red clover, wild yam, hops and three species of licorice.

An earlier paper in the Journal of the American Society for Mass Spectrometry described tailoring the novel method, affinity selection mass spectrometry, to finding drugs that would target the SARS-CoV-2 spike protein.

In the later research, lab tests showed that cannabigerolic acid and cannabidiolic acid prevented infection of human epithelial cells by the coronavirus spike protein and prevented entry of SARS-CoV-2 into cells.

“These compounds can be taken orally and have a long history of safe use in humans,” van Breemen said. “They have the potential to prevent as well as treat infection by SARS-CoV-2. CBDA and CBGA are produced by the hemp plant as precursors to CBD and CBG, which are familiar to many consumers. However, they are different from the acids and are not contained in hemp products.”

Van Breemen explains that affinity selection mass spectrometery, which he abbreviates to AS-MS, involves incubating a drug target like the SARS-CoV-2 spike protein with a mixture of possible ligands – things that might bind to it – such as a botanical extract, in this case hemp extract.

The ligand-receptor complexes are then filtered from the non-binding molecules using one of several methods.

“We identified several cannabinoid ligands and ranked them by affinity to the spike protein,” van Breemen said. “The two cannabinoids with the highest affinities for the spike protein were CBDA and CGBA, and they were confirmed to block infection.

“One of the primary concerns in the pandemic is the spread of variants, of which there are many, and B.1.1.7 and B.1.351 are among the most widespread and concerning,” he added. “These variants are well known for evading antibodies against early lineage SARS-CoV-2, which is obviously concerning given that current vaccination strategies rely on the early lineage spike protein as an antigen. Our data show CBDA and CBGA are effective against the two variants we looked at, and we hope that trend will extend to other existing and future variants.”


Van Breemen said resistant variants could still arise amid widespread use of cannabinoids but that the combination of vaccination and CBDA/CBGA treatment should make for a much more challenging environment for SARS-CoV-2.

“Our earlier research reported on the discovery of another compound, one from licorice, that binds to the spike protein too,” he said. “However, we did not test that compound, licochalcone A, for activity against the live virus yet. We need new funding for that.”

Timothy Bates, Jules Weinstein, Hans Leier, Scotland Farley and Fikadu Tafesse of OHSU also contributed to the cannabinoid study.

You’re welcome heathens.




ZRX1200 Offline
#2 Posted:
Joined: 07-08-2007
Posts: 60,477
I hear Opie is up to date and is boostering the 💩 outta himself.
DrMaddVibe Offline
#3 Posted:
Joined: 10-21-2000
Posts: 55,309
Oregon - A Gateway State
Speyside2 Offline
#4 Posted:
Joined: 11-11-2021
Posts: 2,307
**** Oregon. With my heart medication CBD is a no go.
deadeyedick Online
#5 Posted:
Joined: 03-13-2003
Posts: 16,961
Only stoners will be left when this is over.
bgz Offline
#6 Posted:
Joined: 07-29-2014
Posts: 13,023
Bow b*tches, where's my bong?
rfenst Offline
#7 Posted:
Joined: 06-23-2007
Posts: 39,112
I didn't read the whole thing, but the takeaway is that smoking copious amounts of weed will prevent covid? Who'd have known, right ZRX?
ZRX1200 Offline
#8 Posted:
Joined: 07-08-2007
Posts: 60,477
Something about “an ounce of prevention”….
HockeyDad Offline
#9 Posted:
Joined: 09-20-2000
Posts: 46,069
It took Oregon almost two years of the pandemic to come up with “Hey, maybe weed will fix it!”

Next they are going to suggest Doritos and Cheetos.
Ram27 Offline
#10 Posted:
Joined: 04-30-2005
Posts: 48,926
Cliff note version please!d'oh!
DrMaddVibe Offline
#11 Posted:
Joined: 10-21-2000
Posts: 55,309
Ram27 wrote:
Spliff note version please!d'oh!



Fixed it for ya mon!
ZRX1200 Offline
#12 Posted:
Joined: 07-08-2007
Posts: 60,477
First paragraph sums it up ya lazy bastids….
Sunoverbeach Offline
#13 Posted:
Joined: 08-11-2017
Posts: 14,588
Why didn't the astronaut come home to his wife?
He needed his space
Mr. Jones Offline
#14 Posted:
Joined: 06-12-2005
Posts: 19,359
Sooooo ..

Do you have to get hemp extracts?
Exact extracts in oil form or CBD FORM?

CAN YOU JUST SMOKE WEED AND GET THE SAME CANIBOID ACIDS?

SOUNDS LIKE MANY NATURAL COMBOS FIGHT DA' COVID

WEED, CBD , CANIBOID ACIDS
WHITE PINE NEEDLE TEA
MILK / lactoferrin and Benadryl / Diphenhydramine combo
Kills covid in lung tissue ..

So why are we forced to take a fast tracked vaccine that is not really a vaccine? Some spike protein acting Frankenstein bull crap "vaccine"...
Smooth light Offline
#15 Posted:
Joined: 06-26-2020
Posts: 3,598
Burning down the house 🏡, sorry sweetie I was making hemp oil, and things got out of hand and burnt the sate forest and I'm in jail 😥!!!
bgz Offline
#16 Posted:
Joined: 07-29-2014
Posts: 13,023
Mr. Jones wrote:
Sooooo ..

Do you have to get hemp extracts?
Exact extracts in oil form or CBD FORM?

CAN YOU JUST SMOKE WEED AND GET THE SAME CANIBOID ACIDS?

SOUNDS LIKE MANY NATURAL COMBOS FIGHT DA' COVID

WEED, CBD , CANIBOID ACIDS
WHITE PINE NEEDLE TEA
MILK / lactoferrin and Benadryl / Diphenhydramine combo
Kills covid in lung tissue ..

So why are we forced to take a fast tracked vaccine that is not really a vaccine? Some spike protein acting Frankenstein bull crap "vaccine"...


Here Jonesy, smoke two of these and call me in the morning... then while you're on hold, smoke two more.
ZRX1200 Offline
#17 Posted:
Joined: 07-08-2007
Posts: 60,477
BGZ you could probably get ME to smoke one if we were with Jonsie…….now THAT would be a camping trip.
Sunoverbeach Offline
#18 Posted:
Joined: 08-11-2017
Posts: 14,588
A man walks into the forest and tries to cut down a talking tree. "You can't cut me down," said the tree, "I'm a talking tree." The man replied, "You may be a talking tree, but soon you will dialogue."
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