johnfs: your brother and family will be kept in my prayers. please post any and all information that you can about your brother -- spreading the word as far and wide as possible is very helpful.
also, please check out http://www.nmco.org/ if you haven't already. assuming that your brother is an adult, the Center For Missing Adults can also be very helpful.
i used to work in law enforcement and handled missing persons cases frequently. if i can be of service in any way, please contact me: BBELTRISI at ec.rr.com
for now, if you will, please post the following here -- just to get the ball rolling:
name:
age:
thorough physical description:
last known location:
any handicaps (mental or physical):
any known medications he was on:
any "guesses" about where he might be:
just for starters, that can get word out here and grow from there.
hang in there.
-sicilian tony