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If you're talking smoke from a structure fire, I'd ask a servicemaster friend.

We have a small smoke room (12x20) detached from the house [really nice actually, full bar, two fridges, insulated, AC, Heat TV]. We never leave a cigar butt in there overnight.

It's hard to tell we smoke in there.

Have your mother in law move out.

It appears refest and Eight have this covered. Read prior wasn't sure if he was looking to remove smoke from Ceegars or something as Big Bear posted.

Rent an ozone generator.

I've used them a few times in the past, always happy with results.

If it's a smoking room you're no longer using and want it really gone, the drywall, trim, insulation, flooring etc all have to come out. Run ozone generator for a day or two, seal the wood with kilz, and put up new finish work. Same for house fires.

They also work for smoked in cars. Deep clean with a carpet/upholstery extractor, ozone generator for a day, and the smell will be 90% gone. I'll usually strip the seats and carpet to clean, then reassemble for ozone.

Thanks guys. Just looking to remove smoke odor from a 2022 Honda Accord I bought recently. The salesman was a smoker. I figured it was him that smelled like smoke, not the car. Unfortunately, it was both.

I’m going to have the carpet and mats shampooed as well as change out the interior air filter. It that doesn’t do it, I’ll borrow/rent an ozone generator.