Years ago, Susan Sarandon in a sun dress could have played his mother along with Yaphet Kotto (dad), Wesley Snipes (destitute brother in Africa), actors who played Ma & Pa Kettle in Superman (grandparents), and George Jefferson's sassy maid, Florence (Michelle Obama). Pick any two of the kids from the Huxtable children for his daughters.
Emmanuel Lewis was perfect for the young Obama.
Harry Belafonte for the future, old Obama.
Sean Penn could resuscitate his classic Jeff Spicoli for Biden.