You know whatever works best for you, and what your threshold dosage for pain relief is, better than anyone else- now that you are using it.
You sure it isn't hydro, rather than oxy? 10/350 is a type of hydrocodone (Lortab, Vicodin as opposed to Percodan or Percocet). What is your doc's prescribed dosage and frequency? The only thing I can say about opiate painkillers is only applicable to my experiences. YMMV!
If the dosing called, for example, 1-2 every 4-6 hours, I would take one first thing in the morning, straight out of bed- even though I might not be hurting enough yet. I would then experiment with taking a second one at two to four hours, rather than two at the same time.
This keeps the amount of drug in my body lower and more constant, hopefully just above the minimum required to give me pain relief. Otherwise, my blood opiate level seems to bounces up and down too much, and I will, at times, have more medicine in me than I truly need and, at other times, less than I need to remain out of pain.
This technique can work to help me take a few less pills per day than just simply taking them every 4-6 hours- too late to prevent return of some or more of the pain...
Catch my drift? If not, I have a book in my office with a graphical explanation of this that I can scan and send you.
What was the particular procedure?
More important, did you check out that link to that website? Pretty sick and scary, huh?