Pudding Mittens
6 years ago

The authors also note the very narrow toxic range of chloroquinone (this is how idiots who try to prescribe for themselves end up in critical care. It has very little to do with the source of the material, aquarium or not)

victor809 wrote:


This is a plus, a valuable bonus of the drug. Not only does it clean aquariums, but gene pools too!*

( *When the idiots die immediately, and aren't admitted to take up hospital resources )
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teedubbya
6 years ago
I’m not arguing just talking. I hope you are right.

The 1-2% death rate factors in too.

Even if effective we don’t want everyone using or trying to use it. Worst cases maybe.

And because of the hype some folks using it for on label uses like lupus are having a rough time getting it.

There are a lot of moving parts.
teedubbya
6 years ago
And other things in the works as well.
Pudding Mittens
6 years ago

I'm thinking it's the same reason people tout some of those cold cures.
With a certain percentage of people who are sick, given time, they get better. [.....] This is why double blinded studies have to be done for any actual believable data

victor809 wrote:


(Sigh). Yes. This is all obvious and I've agreed to it many times. Yes, yes I know. Yes. No, really, I know. Honest. Yes. See above. We've been over all this already.

And here's my reply, repeated again:

The fact remains that a bunch of partial bits of data all collectively strongly hint that it may be effective, and these are exigent circumstances and the stuff is relatively safe for most people when under a doctor's supervision and it's only a 5-day course, and for many patients it's worth the risk to try it off-label and see if it works before the formal study results that we absolutely need eventually but will come too late for lots of people.

To prevent endless further repetitions of this, from now on, whenever anyone starts with this I'm just going to say "See post #384 above". Nice quick shorthand so I don't have to keep typing this same stuff over and over.
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victor809
6 years ago

(Sigh). Yes. This is all obvious and I've agreed to it many times. Yes, yes I know. Yes. No, really, I know. Honest. Yes. See above. We've been over all this already.

And here's my reply, repeated again:

The fact remains that a bunch of partial bits of data all collectively strongly hint that it may be effective, and these are exigent circumstances and the stuff is relatively safe for most people when under a doctor's supervision and it's only a 5-day course, and for many patients it's worth the risk to try it off-label and see if it works before the formal study results that we absolutely need eventually but will come too late for lots of people.

To prevent endless further repetitions of this, from now on, whenever anyone starts with this I'm just going to say "See post #384 above". Nice quick shorthand so I don't have to keep typing this same stuff over and over.
.

Pudding Mittens wrote:



You're right and wrong.

Or right and selectively blind.

You see the "bunch of partial bits of data ..... hint may be effective" which yes, is why people will test it.
But you seem blind to the prior in vivo studies which saw no effect (or negative impact)

You're right we keep going around. But you bring up additional anecdotal evidence, and think it's adding to the burden of evidence that we should be using this drug.
Danm just provided anecdotal evidence that it does nothing... but that doesn't seem to put any brakes on your enthusiasm....

Just seems odd to me. This is a medicine which is necessary for some people in general... has anecdotal evidence of helping some with coronavirus, has other anecdotal evidence of helping no one with coronavirus... has actual data that in vivo doesn't help... and has some non-zero risk to patients. Maybe we should put the brakes on it a little, and make sure the people who actually need it, who it works for, have it available while a test is done.
Pudding Mittens
6 years ago
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Victor, it really all boils down to risk-benefit analysis. That's essentially the whole thing. Without correctly-designed study results, that analysis is not easy.

The M.D.s just have to do what they think is best on a patient-by-patient basis. For many patients, it'll be worth a shot, if the two drugs aren't contraindicated for them personally. For others it won't be worth a shot.

I wouldn't want to be an M.D. who has to make these life/health-impacting decisions for others with very limited data available. Makes me glad I went into software instead. 🇨🇮
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teedubbya
6 years ago
By definition that wouldn’t make it a miracle drug as being pushed my non medical folks, fox, and the prez.

I’m still hopeful for it and about a half dozen equally promising treatments yet to be completely vetted. Danms post is sobering to me though. I believe him.

In the end it’s largely irrelevant given the timeline we are on.
teedubbya
6 years ago
I am fascinated by the vaccine efforts. Bill Gates discussed it a bit last night.

I also learned we began working on it the evening (1/10) we received the genetic sequence from China. Three days later NIH shared their vaccine sequence with a manufacturer. 3/16 the first human received the trial vaccine. May not seem like it but that’s phenomenal.
teedubbya
6 years ago
Thinking through it we’ve missed an important opportunity. Has anyone consulted with Chuck Norris or RAM?
opelmanta1900
6 years ago
You have access to fgm's account?
teedubbya
6 years ago
Lol. Deleted that post but it was funny while it lasted.
opelmanta1900
6 years ago
delta1
6 years ago
dammit...I missed it...was busy with the grandkids this morning...

and I really needed a good laugh, and who better to laugh at than FGM?
Pudding Mittens
6 years ago

Thinking through it we’ve missed an important opportunity. Has anyone consulted with Chuck Norris or RAM?

teedubbya wrote:


The coronavirus is terrified of catching Chuck Norris.
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delta1
6 years ago
Kung flu fighting...but didn't Bruce Lee kick his ass?
Pudding Mittens
6 years ago

I am fascinated by the vaccine efforts. Bill Gates discussed it a bit last night.

I also learned we began working on it the evening (1/10) we received the genetic sequence from China. Three days later NIH shared their vaccine sequence with a manufacturer. 3/16 the first human received the trial vaccine. May not seem like it but that’s phenomenal.

teedubbya wrote:


Yeah, if I remember right it took like 2 years after SARS to get the first vaccine trial started.
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danmdevries
6 years ago

I am fascinated by the vaccine efforts. Bill Gates discussed it a bit last night.

I also learned we began working on it the evening (1/10) we received the genetic sequence from China. Three days later NIH shared their vaccine sequence with a manufacturer. 3/16 the first human received the trial vaccine. May not seem like it but that’s phenomenal.

teedubbya wrote:



It'll be a long way off tho.

We're going to need to analyze antibodies from recovered patients, and track them for a good amount of time (and they gotta stay alive too)

The issue is the physical damage that is done to the lung tissue by initial exposure to the virus. It's not just an inflammatory/immune response. This causes physical damage to the cells that do the air exchange.

victor809
6 years ago


The issue is the physical damage that is done to the lung tissue by initial exposure to the virus. It's not just an inflammatory/immune response. This causes physical damage to the cells that do the air exchange.

danmdevries wrote:


Saw you mention this before.
Gotta admit, that part's worse than I thought....
danmdevries
6 years ago

Saw you mention this before.
Gotta admit, that part's worse than I thought....

victor809 wrote:



Yup.

That's why all of "us" are scared. We can treat the other stuff. We can't treat this. And we're highly susceptible because it seems like the initial exposure viral load correlates with severity of symptoms in the otherwise healthy. And we're dealing with this without proper PPE. I'd walk into a room with the confidence and swagger of McGregor if I had the proper equipment. But we don't. We don't have goggles/face shields. We don't have respirators. We get a face mask that does fxckall to protect us.

This needs to be thought of as like a toxic corrosive gas cloud more than a virulent pathogen. We're all used to the flu, the cold, and other ailments major or minor. You recover and go back to your normal. This is different. You recover, but the damage remains. It's like inhaling a cloud of acid that burns your lungs.
teedubbya
6 years ago
Agreed damn. Long way off as impressive as it is.

That’s the problem between the miracle drugs and vax. This things moving so fast and while great won’t meet the needed time frame.

This is just the beginning and it’s ugly. It’s been hard to get that through to some.
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