Hey, a couple of quick thoughts. If you're completely imaging the disk (loading entire disk via image), then it shouldn't matter what format the new drive has, it'll be overwritten with the old drive format. Basically, Ghost will blow away the new drive with an exact copy of the old drive. Therefore, you'll get NTFS on the new drive.
But, having said that, my first question would be are you imaging or just copying folders?
If you're keeping the OS on the new box (copying folders), you might have problems with a machine running Win9x (Win95, Win98, WinMe), as I don't think NTFS is recognizable in those OS's. So, when the machine boots, those folders/data might have a problem. Definitely not Win95, perhaps the others. Still, it shouldn't matter if you're imaging (not copying), as the entire drive is wiped.
Also, you can change the format of the new drive (assuming that it's up and runnning) by running convert drive_letter: /fs:ntfs at the command prompt.
Sounds like the tech support from Symantec has his head up his rear, or there's more information I don't know. Tell me more, and I'll do what I can to help. I need to know what you're running, what you're putting it into--basically tell me everything.
One final note: If you're imaging from existing drive to brand new computer (a different box), then the device drivers, windows updates, and all else wouldn't necessarily match, and you'll have issues getting all of the display, network, modem, etc, to work. If you're keeping the same box, then forget what I just said.
Stuart