This study is 10,000-to-1 against chance. This means the probability of the study's findings being wrong (which would mean that two-drug combo is not effective) is THE SAME as the probability of you walking into a store and buying just a single "Pick 4" lottery ticket (the kind with four digits each from 0-9) and matching the drawn number perfectly..

Hence my optimism about the two-drug combo. About 4-5 more days and I suspect we'll be hearing the "wow!" reports coming in from the field, even though the large-scale, tightly-controlled, formalized study's results will be months away. But if so, nobody will care much about the formal study, it'll be "off to the races" with mass deployment for curing and possibly prevention too (given to healthcare workers first, likely, as they're at highest risk).
.

Pudding Mittens wrote:

Is that a Cardinal rule?

izonfire wrote:

Yes, it actually is. I'm a member.

USNGunner wrote:

There are no popes in the Church of the Flying Spaghetti Monster.

tonygraz wrote:

Pastarianism

Why should you convert?

*Flimsy moral standards.

*Every Friday is a religious holiday. If your work/school objects to that, demand your religious beliefs are respected and threaten to call the ACLU.

*Our Heaven is WAY better. We've got a Stripper Factory AND a Beer Volcano.


Behold I have been touched by his noodly appendage!

CelticBomber wrote:

Pastarianism

Why should you convert?

*Flimsy moral standards.

*Every Friday is a religious holiday. If your work/school objects to that, demand your religious beliefs are respected and threaten to call the ACLU.

*Our Heaven is WAY better. We've got a Stripper Factory AND a Beer Volcano.


Behold I have been touched by his noodly appendage!

CelticBomber wrote:

.
We could all use some GOOD news about this, right?

GOOD NEWS BIT #1:

Well, here's a positive thing I failed to mention earlier. You know that French study where hydroxychloriquine and azithromycin together cured 100% of people after 5-6 days?

I mentioned it was hastily done and had many inadequacies (only 6 people got the two-drug combo and were cured, it was non-randomized and non-blinded, etc.)

Those are fairly dim clouds cast over the study, however, if you look at the statistical analysis, things get much brighter. "Significance" is generally agreed to begin when a result is 20-to-1 against chance (meaning there's only a 1 out of 20 probability that it happened randomly and the effect indicated is not real).

This study is 10,000-to-1 against chance. This means the probability of the study's findings being wrong (which would mean that two-drug combo is not effective) is THE SAME as the probability of you walking into a store and buying just a single "Pick 4" lottery ticket (the kind with four digits each from 0-9) and matching the drawn number perfectly.

GOOD NEWS BIT #2:

Remember I mentioned Africa having a very low infection rate, possibly because they use chloroquine / hydroxychloriquine widely for prevention and treatment of malaria?

Turns out it isn't just Africa. Southeast Asia and South America also use the drug widely for the same reason.

Guess who also has almost no COVID-19 cases? Yeah, Southeast Asia and South America. It's not just one data point (Africa) now, it's three, which is a considerably stronger confidence level.

Hence my optimism about the two-drug combo. About 4-5 more days and I suspect we'll be hearing the "wow!" reports coming in from the field, even though the large-scale, tightly-controlled, formalized study's results will be months away. But if so, nobody will care much about the formal study, it'll be "off to the races" with mass deployment for curing and possibly prevention too (given to healthcare workers first, likely, as they're at highest risk).
.

Pudding Mittens wrote:

Oh... BTW our idiot of a president of course decided to tweet "HYDROXYCHLOROQUINE & AZITHROMYCIN, taken together, have a real chance to be one of the biggest game changers in the history of medicine. The FDA has moved mountains - Thank You! Hopefully they will BOTH (H works better with A, International Journal of Antimicrobial Agents) be put in use IMMEDIATELY. PEOPLE ARE DYING, MOVE FAST, and GOD BLESS EVERYONE!"
Which has led to a couple people in Africa taking the drug combo at incorrect doses and becoming ill.

victor809 wrote:

You people trusted a study from France. Sweet!

HockeyDad wrote:

With factories shut down, people staying home, and sheltering in place... the corona virus has done more for the environment in a couple weeks than Greta Thunberg ever did. 😰

Just saying... 🤣

MACS wrote:

we should expect that drugs intended as a cure are effective and safe...can't approve a drug that may cause severe and long-lasting side-effects...hope the FDA can figure out ways to accelerate the testing...

the numbers are beginning to look daunting...

delta1 wrote:

Al if they use existing drugs it would expedite the process.

ZRX1200 wrote:

Honestly.... we can.

This has been my problem with pharma for a decade. And I was part of this problem. Everything has to be tested to reduce risk to the smallest level possible.

F#ck... I think a lot of people would be ok with their drugs sometimes having a chance of causing birth defects... if they were 1/2 the price and could be rolled out 10x faster.

We could roll any wild thing out we wanted.... let people self medicate to see what works... let your idiotic facebook friends be the ones to tell you what to use to get medical care if you want. if it works, great... if it doesn't and you die? meh.

But no one lets me run the country.

victor809 wrote:

^So that's why you're a liberal. 🤣

Sorry, Al... you just left that there.

MACS wrote:

^So that's why you're a liberal. 🤣

Sorry, Al... you just left that there.

MACS wrote: