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Mittens, I hope and pray you are right. But people are hoarding medications that probably won't work. People with Lupus need hydocloroquin. They can't find it, this is a tragedy.

If you're relying on the .gov to "save" you? Hell, you've lost already. They can't stop anything. Period.

The corruption and lack of actual, functional accountability runs way too deep. Look at their latest response. If it weren't so fucquing sad it would be laughable.

The individual level is the only thing that WILL work. Nobody is responsible for you and yours but you. Folks need to pay attention and accept personal responsibility.

A little more self reliance, self-determination, and awareness would go a long damned way in this country.

updated info all footnoted... the foots are not linked here but I can get any of them. This is pulled from a much larger set of practice protocols.

Investigational agents — A number of investigational agents are being explored for antiviral treatment of COVID-19, and enrollment in clinical trials should be discussed with patients or their proxies. A registry of international clinical trials can be found on the WHO website and at clinicaltrials.gov.

Certain investigational agents have been described in observational series or are being used anecdotally based on in vitro or extrapolated evidence. It is important to acknowledge that there are no controlled data supporting the use of any of these agents, and their efficacy for COVID-19 is unknown.

●Remdesivir – Several randomized trials are underway to evaluate the efficacy of remdesivir for moderate or severe COVID-19 [95]. Remdesivir is a novel nucleotide analogue that has activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro and related coronaviruses (including SARS and MERS-CoV) both in vitro and in animal studies [96,97]. The compassionate use of remdesivir through an investigational new drug application was described in a case report of one of the first patients with COVID-19 in the United States [98]. Any clinical impact of remdesivir on COVID-19 remains unknown.

●Chloroquine/hydroxychloroquine – Both chloroquine and hydroxychloroquine have been reported to inhibit SARS-CoV-2 in vitro, although hydroxychloroquine appears to have more potent antiviral activity [99].

Use of chloroquine is included in treatment guidelines from China's National Health Commission and was reportedly associated with reduced progression of disease and decreased duration of symptoms [100,101]. However, primary data supporting these claims have not been published [102].

Other published clinical data on either of these agents are limited. In an open-label study of 36 patients with COVID-19, use of hydroxychloroquine (200 mg three times per day for 10 days) was associated with a higher rate of undetectable SARS-CoV-2 RNA on nasopharyngeal specimens at day 6 compared with no specific treatment (70 versus 12.5 percent) [103]. In this study, the use of azithromycin in combination with hydroxychloroquine appeared to have additional benefit, but there are methodologic concerns about the control groups for the study, and the biologic basis for using azithromycin in this setting is unclear. (See "Azithromycin (systemic): Drug information".)

Despite the limited clinical data, given the relative safety of short-term use of hydroxychloroquine, the lack of known effective interventions, and the in vitro antiviral activity, some clinicians think it is reasonable to use hydroxychloroquine (or chloroquine) in hospitalized patients with severe or risk for severe infection if they are not eligible for other clinical trials. The possibility of drug toxicity (including QTc prolongation and retinal toxicity) should be considered prior to using hydroxychloroquine, particularly in individuals who may be more susceptible to these effects. Optimal dosing is uncertain; various regimens are being used, including 400 mg twice daily on day 1 then daily for five days, 400 mg twice daily on day 1 then 200 mg twice daily for four days, and 600 mg twice daily on day 1 then 400 mg daily for four days [104].

●Tocilizumab – Treatment guidelines from China's National Health Commission include the IL-6 inhibitor tocilizumab for patients with severe COVID-19 and elevated IL-6 levels; the agent is being evaluated in a clinical trial [105].

●Lopinavir-ritonavir – Lopinavir-ritonavir appears to have little to no role in the treatment of SARS-CoV-2 infection. This combined protease inhibitor, which has primarily been used for HIV infection, has in vitro activity against the SARS-CoV [106] and appears to have some activity against MERS-CoV in animal studies [107]. However, there was no difference in time to clinical improvement or mortality at 28 days in a randomized trial of 199 patients with severe COVID-19 given lopinavir-ritonavir (400/100 mg) twice daily for 14 days in addition to standard care versus those who received standard of care alone [108].

Other interventions of interest but with limited or no clinical data include interferon beta and convalescent serum.

I wish I could paste the link or the whole schpeel. It is an excellent well documented source meant to give treatment guidelines and protocols on pretty much everything..... its updated continually

^ dunno. I trust them though.

Found this interesting. SOmeone was asking me about UV the other day... cant remember who.

Strategies for PPE shortages — Limited availability of personal protective equipment (PPE) has complicated medical care of patients with suspected or documented COVID-19 (and other transmissible conditions) worldwide.

In the United States, the CDC offers guidance on optimizing the supply of PPE when sudden increases in patient volume threaten a facility's PPE capacity [114]. Strategies include canceling non-urgent procedures or visits that would warrant use of PPE, prioritizing the use of certain PPE for the highest risk situations, and cautious extended or limited reuse of PPE.

There has also been interest in decontamination of PPE for reuse, in particular for N95 respirators. Decontamination with ultraviolet (UV) light was evaluated in the context of the H1N1 influenza pandemic; in experimental models, UV irradiation was observed to reduce H1N1 influenza viability on N95 respirator surfaces at doses below the threshold observed to impair the integrity of the respirator [115-117]. Coronaviruses can also be inactivated by UV irradiation, but comparable studies have not been performed with SARS-CoV-2, and the dose needed to inactivate the virus on a respirator surface is unknown. Nebraska Medicine has implemented a protocol for UV irradiation of N95 respirators in the context of the COVID-19 pandemic based on the dose generally needed to inactivate other single-stranded RNA viruses on surfaces [118].

Duke University Health System is using hydrogen peroxide vapor for N95 decontamination [119]. Hydrogen peroxide vapor has been observed to inactivate other single-stranded RNA viruses on environmental surfaces [120,121].

Equipment used for protection in other industries is also being explored as an alternative to standard health care PPE, such as elastometric half-mask respirators in place of N95 respirators [122].

In the next hour or so it will kill more Americans than 911.

I saw the FDA release an hour ago or so.
No real new information in it, just "authorized" for use. They're already doing so.

As for the Dr. Zelenko stuff.... there's a LOT about what's in that which I simply cannot trust.
It's not a study... He calls it one. But really he's just treated a bunch of his patients with the drugs. There's zero controls... No results testing other than "shortness of breath after 4-6 hours".

I suspect that we'll find out after the fact that there's no impact at all from the drugs.

maybe.
without our own pool of infected patients, a blinding protocol and PCR machine, we're just guessing.

#515 ^

we're gonna have ample opportunity to do that...the vaccine is at least 12 months away and nothing else seems to work with any degree of certainty...

if it was me or a family member on the ventilator, and they asked me if I'd like to try it....yep I would...

Baghdad Bob show is on. Must see TV.

“I’d give you examples but we don’t want to be controversial”

It needs. Laugh track.

Good grief. I didn't see it, but if he's taking credit for the "system" working now... somebody punch him in the face.

He did inherit a gov't that was ill prepared for this, but that goes back more than a few presidents. Nobody saw this coming and our reaction to it has been an absolute fn scramble. Just like pretty much every other country.

I’m just afraid the marketing strategy of nobody knew is going to work. I watched a ton of work get tossed away. Much of it now has been resurrected. But pay no attention to Baghdad Bob the man behind the screen.

So ill prepared that he was walked through a Global Pandemic response when his administration took office.

https://thehill.com/policy/healthcare/488069-obama-officials-walked-trump-aides-through-global-pandemic-exercise-in-2017

half will call it TDS

I saw on the news where an elderly woman in a nursing home was infected with the corona and given 24 hours to live - she had a cup of potato soup and quickly and fully recovered. There's probably going to be a run on potato soup and potatoes.

A pandemic scenario was part of our national emergency planning process. It was assigned to the Department of Health and Human Services to promulgate and implement.

The Obama Administration updated the original plan from 2005 after the H1N1 outbreak in 2010. Most large governmental agencies and local, state and federal levels were expected to participate in a nationwide tabletop exercise regarding a pandemic outbreak in April 2015.

The latest plan was updated after the Trump administration took office in 2017. It calls for coordination by the HHS of resources between state and local government and the international communities.

https://www.cdc.gov/flu/pandemic-resources/pdf/pan-flu-report-2017v2.pdf

"7. Domestic and International Response Policy, Incident Management, and
Global Partnerships and Capacity Building - HHS will continue to coordinate both
domestic and international pandemic preparedness and response activities. This will
include having clearly defined mechanisms for rapid exchange of information, data,
reagents and other resources needed domestically and globally, to prepare for and
respond to an influenza pandemic outbreak."


to say that nobody knew this was coming is not true...

Me too. But in reality given personal responsibility and all....isn’t it still mostly on trump? Not he made me mad so I killed her? But I hear ya.

The top secret surplus. stock... ignored ....

In other words I agree with you that Obama did that and it was dumb and it pissed Trump off. However I think it’s a long stretch to be able to blame trumps actions on Obama. I think it does explain some of it that is true but it doesn’t absolve trump from his own actions

.
(Skips political blame-game posts, waits for more experimental data, both lower-quality exigent-circumstances data now, and high-quality controlled data later).
.

#534 ^

Hey 8...you know that happened after a year of unrelenting Birther Attacks publicly promoted by Trump...Trump and his peeps started questioning Obama's citizenship in March 2010, as part of his slow roll-out of his presidential aspirations...

Trump became the face of the Birther Movement in March 2011, in an interview on Good Morning America, when he questioned Obama's citizenship, and repeated his allegations on the View later that month. In early April, 2011 Trump was interviewed on NBC, and said he wasn't satisfied that Obama had proved his citizenship. Obama had the state of Hawaii release his certificate of live birth, on April 27, 2011.

Then on April 28, 2011, Obama fired back at the WH Correspondents dinner...

and in his final speech at the WH corespondents dinner in April 12016, he unloaded on Trump again...

everybody knows the WH Correspondents dinner is supposed to be fun and games...entertainment


Trump is the bigger arse in this one...intentionally and maliciously promoting a lie as the honest truth to discredit a sitting POTUS and to get recognition as a POTUS candidate himself...

and he hasn't changed since, promoting many more lies to rewrite history so he can look more favorable to himself and his supporters who willingly believe his lies...

Smart... been posting on this site for damn near 16 years (holy crap!), and the arguments here have never changed a single mind. You're in one camp or the other.

It all depends on your perspective. Principled men don't always stand of principles. If they did, Trump wouldn't be the president.

so let me get this straight.

Trump spends a couple years claiming obama wasn't born in the US, faked his birth certificate etc... making a huge ruckus over the whole thing....
Obama takes one night to make fun of the guy who's spent a couple years engaged in a racist campaign against him...
And we're saying Obama is to blame for that idiot becoming president and trying to tear down everything obama was involved in? Even partially?

That's....insane. And enough irony (that it's coming from the "party of personal responsibility") to kill a mime.

hell. the people really to blame in this case would be the people who voted for someone who's entire goal was to become president and destroy everything obama created because he was mean to him one night.... Seems like they're the ones who enabled this child to go and kick the sandcastle down.

There's enough blame to go around.

9.11 changed everything.